What class of drug is eplerenone?
What class of drug is eplerenone?
Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
Why is eplerenone use in heart failure?
In the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS),3 the selective mineralocorticoid-receptor antagonist eplerenone, added to recommended medical therapy, reduced the rates of death from any cause and hospitalization for cardiovascular reasons among patients with …
When should I start eplerenone in Hfref?
In patients with HFREF early postMI and in patients with mild–moderate HFREF, similar to those included in EPHESUS and EMPHASIS-HF trials, eplerenone at a dose of 25–50 mg/day, due to its favorable risk:benefit ratio and proven efficacy, would appear to be the MRA of choice.
Which is better eplerenone vs spironolactone?
In summary, the data of eplerenone use in resistant HTN are encouraging but currently appear to trail those reported with the use of spironolactone. However, for patients developing anti-androgenic side effects from spironolactone, eplerenone is efficacious and better tolerated and thus a good alternative.
Why is eplerenone used?
It’s used to treat heart failure and reduce the risk of you having other heart problems or a stroke. It also helps to stop heart failure getting worse. It can sometimes be used to treat a condition called hyperaldosteronism. This is when your body makes too much aldosterone, a hormone that controls your blood pressure.
What eplerenone is used for?
Eplerenone belongs to the general class of medicines called antihypertensives. It is used alone or together with other medicines to treat high blood pressure (hypertension). This medicine is also used to treat congestive heart failure (CHF) after a heart attack.
Does eplerenone affect heart rate?
There was no effect of eplerenone on heart rate. At the lower doses of 50 mg and 100 mg/d, twice-daily dosing (ie, 25 mg bid and 50 mg bid) reduced seated systolic and diastolic blood pressures to a greater extent than did once-daily dosing. Eplerenone also significantly decreased ambulatory blood pressure.
How does eplerenone differ from spironolactone?
Pharmacological differences between spironolactone and eplerenone include lower affinity of eplerenone for progesterone, androgen, and glucocorticoid receptors; more consistently demonstrated nongenomic properties for eplerenone; and the presence of long-acting metabolites for spironolactone.
What is eplerenone made of?
Eplerenone is also known chemically as 9,11α-epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone and “was derived from spironolactone by the introduction of a 9α,11α-epoxy bridge and by substitution of the 17α-thoacetyl group of spironolactone with a carbomethoxy group.” The drug controls high blood …
Who makes eplerenone?
Pfizer Limited
Manufacturer’s PIL, Inspra® 25 mg and 50 mg film-coated tablets; Pfizer Limited, The electronic Medicines Compendium.
Does eplerenone increase BP?
Stopping eplerenone may cause your blood pressure to rise, and this may increase your risk of a heart attack, stroke or heart failure getting worse. If you are bothered by side effects, your doctor may be able to prescribe you a different medicine.
What is the advantage of eplerenone over spironolactone?
A major advantage of eplerenone over the nonselective aldosterone receptor antagonist spironolactone is lack of binding to progesterone and androgen receptors, which is associated with drug-induced gynecomastia, breast pain, and impotence.
